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The Psychobiology of Bulimia Nervosa pp Cite as. The relationship between eating disorders and affective disorders has generated considerable interest in the past decade. Because descriptions of bulimia and anorexia nervosa suggest many points of phenomenological similarity to depression, it has been argued that these eating disorders are each a variant of affective disorder Hudson and Pope ; Hudson et al. Further evidence has been drawn from neuroendocrine similarities, response of eating disorder patients to antidepressant medication, and family studies for review see Strober and Katz Unable to display preview. Download preview PDF.
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Anorexia nervosa AN has the highest mortality rate between psychiatric disorders, and evidence for managing it is still very limited. So far, pharmacological treatment has focused on a narrow range of drugs and only a few controlled studies have been performed. Furthermore, the studies have been of short duration and included a limited number of subjects, often heterogenic with regard to stage and acute nutritive status. Thus, novel approaches are urgently needed. Body weight homeostasis is tightly regulated throughout life. With the discovery of orexigenic and anorectic signals, an array of new molecular targets to control eating behavior has emerged. This review focuses on recent advances in three important signal systems: leptin, ghrelin, and endocannabinoids toward the identification of potential therapeutical breakthroughs in AN. Our review of the current literature shows that leptin may have therapeutic potentials in promoting restoration of menstrual cycles in weight restored patients, reducing motor restlessness in severely hyperactive patients, and preventing osteoporosis in chronic patients. Ghrelin and endocannabinoids exert orexigenic effects which may facilitate nutritional restoration. Leptin and endocannabinoids may exert antidepressive and anxiolytic effects.
Translate texts with the world's best machine translation technology, developed by the creators of Linguee. Look up words and phrases in comprehensive, reliable bilingual dictionaries and search through billions of online translations. DeepL Translator Linguee. Open menu. Translator Translate texts with the world's best machine translation technology, developed by the creators of Linguee. Linguee Look up words and phrases in comprehensive, reliable bilingual dictionaries and search through billions of online translations. Blog Press Information Linguee Apps. Depression f — depression n. Loss of vita lit y, tiredness, depression, lac k o f con ce ntration, [ Der Vorteil war auch in seiner Abwesenheit zum Ausdruck, ja.